Investigating Resistance in ROS1+ Lung Cancer
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Robert C. Doebele, MD, PhD, associate professor at University of Colorado, discusses resistance in patients with ROS1-positive lung cancer. According to Doebele, studies are still early in this field, but 2 have been published so far. Based on data published from the University of Colorado, about 10% of patients showed resistance to ROS1, while the study from Massachusetts General Hospital showed about 50%. While these results are very different, both studies were relatively small. Doebele believes it might be around 30% as with ALK+ lung cancer. Drugs need to be developed to overcome ROS1, but first investigators must identify what types of resistance occurs in these patients. For more resources and information regarding anticancer targeted therapies: http://targetedonc.com/resource-center/lung/